I often get asked if there are any reasons not to get Botox. So, the purpose of this article is to answer that question. I reached out to my friend, Gretch, a.k.a @NeverTox, to get some solid statistics. And the short answer is yes!

Botulinum toxin goes by many names – Botox, Dysport, Jeuveau, Daxxify, etc. Derived from the Clostridium bacteria that causes botulism, it’s become a standard in facial aesthetic treatments.

If you’ve been wary of getting on the “Tox Train,” that’s a good thing. Recent studies are now showing the negative consequences of Botox®. It interferes with interpersonal communication. It stifles your enjoyment of sex. Botox® messes with the wiring of your brain. And there’s more…

Botox causes muscle atrophy.

Botulinum toxin causes muscle weakness and atrophy often leading to a more aged appearance. This is a direct result of denervation. In addition, causing repeated paralysis to a muscle or group of muscles inhibits their normal movement and function. Repeated paralysis over even a short period of time also causes muscle wasting from lack of movement. Further, injecting Botox into a weakened muscle has a high risk for adverse events associated with toxin spread, such as acquiring botulism or other negative systemic reactions.

Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures

Jessica Pingel, Mikkel Schou Nielsen, Torsten Lauridsen, Kristian Rix, Martin Bech, Tine Alkjaer, Ida Torp Andersen, Jens Bo Nielsen & R. Feidenhansl



Long-term Effects of Botulinum Toxin on Neuromuscular Function

Christiane G. Frick, M.D.; Martina Richtsfeld, M.D.; Nita D. Sahani, M.D.; Masao Kaneki, M.D., Ph.D.; Manfred Blobner, M.D.; J A. Jeevendra Martyn, M.D., F.R.C.A., F.C.C.M.


Botox (botulinum toxin A) is the most lethal poison known.

It is incomprehensibly toxic. It is well documented as a biological weapon developed to be used as a war agent. A mere one gram of botulinum toxin is enough to eradicate over a million people.

Botulinum toxin: Bioweapon & magic drug

Ram Kumar Dhaked, Manglesh Kumar Singh, Padma Singh, and Pallavi Gupta



Botox is not measured in weight or volume.

Botox is dosed in Mouse Units, (MUs) this is a calculated median for the amount of toxin delivered all at once to be fatal to a 20g Swiss mouse. When a human receives 100 units of Botox, this is equivalent to the amount of toxin it took to be fatal to 50, 20g mice.

“One Unit of BOTOX® corresponds to the calculated median lethal dose (LD50) in mice. The method utilized for performing the assay is specific to Allergan’s product, BOTOX®.”  [Botoxcosmetic.com]

Botox utilizes cruel and inhumane practices against animals.

Millions upon millions of innocent mice are horrifically & brutally sacrificed by the manufacturers of Botox. Every single batch is animal tested to the death before it reaches consumers. The animal is given its lethal dose and dies of respiratory paralysis or cardiac arrest 3-4 days after injection.

” IN VIVO TESTING OF BOTULINUM TOXINS FOR MEDICAL USE Mouse lethality bioassay (MLB) For botulinum toxin products used for medical purposes, animal testing has been exclusively employed for assessing efficacy and safety. The in vivo MLB is a standard test to evaluate the potency of botulinum toxin [Dressler et al., 2000; Lindström and Korkealla, 2006.] In this assay, the biological activity of a sample is compared with that of standard samples. For decades, the LD50 assay has been the only method to determine the safety and potency of each batch of botulinum toxin manufactured for medical and cosmetic uses. Different doses of botulinum toxin are injected intraperitoneally into mice to assess mortality. Based on animal deaths observed in each group, the potency of botulinum toxin is calculated [Dressler et al., 2000; Lindström and Korkealla, 2006.]”

Botox carries an FDA black box warning label.

This is the strictest warning label provided by the FDA. This label states that using the product can cause death, disability, or even botulism. Adverse events can happen on the first injection, the fifth, or fifteenth. Any amount of the toxin spreading outside of the muscle, going into the bloodstream, or traveling along the central nervous system pathways can cause Iatrogenic Botulism Poisoning, (IBP.) It can happen to any person, from any set of injections – by any provider. Adverse events can begin “days, weeks, or months” after the initial set of injections.

[Botox prescribing info. & medication guide]


It is widely accepted that Botox can travel into your brain and central nervous system.

Industry professionals often see this fact as a therapeutic opportunity, meanwhile thousands upon thousands of people have developed life-altering or severe adverse CNS events after Botox treatment.

Join the Botox Dysport Side Effects Support group on FB to see user experiences.


Featured ArticleArticles, Development/Plasticity/Repair

Long-Distance Retrograde Effects of Botulinum Neurotoxin A

Flavia Antonucci, Chiara Rossi, Laura Gianfranceschi, Ornella Rossetto and Matteo Caleo


Botulinum Neurotoxins in Central Nervous System: An Overview from Animal Models to Human Therapy

Siro Luvisetto


Off-Label (Unapproved) Botox use is rampant in the cosmetic injectables industry.

Off-label use is not studied for safety or efficacy. The long-term effects of off-label use are unknown. Over ⅔ of Botox use is considered off label. Examples of off label treatments include but are not limited to Botox for: bunny lines, smile lift, masseter reduction, eyebrow lift, vertical lip lines, neck bands, calf muscles, swan neck, gummy smile, hand botox etc.

“Serious Adverse Reactions with Unapproved Use Serious adverse reactions, including excessive weakness, dysphagia, and aspiration pneumonia, with some adverse reactions associated with fatal outcomes, have been reported in patients who received BOTOX injections for unapproved uses. In these cases, the adverse reactions were not necessarily related to distant spread of toxin, but may have resulted from the administration of BOTOX to the site of injection and/or adjacent structures. In several of the cases, patients had pre-existing dysphagia or other significant disabilities. There is insufficient information to identify factors associated with an increased risk for adverse reactions associated with the unapproved uses of BOTOX. The safety and effectiveness of BOTOX for unapproved uses have not been established.” [Botox Prescription Guide]

There is an intense lack of hands-on training for Botox injectors.

Botox injectors often only receive a weekend seminar prior to certification to administer the product. These trainings are often led by manufacturer sales reps, or other industry professionals who receive kickbacks. Some training is even done only online. This is a massive issue in patient safety for a product that carries a risk of death from its use.

Using Botox exposes you to a human blood product, albumin.

BOTOX contains human albumin, a human blood product. Because of this ingredient in Botox the risk of transmission of blood-borne pathogens such as viruses, bacterias, parasites, and prion diseases can NEVER be ruled out from its use.

“Each vial of BOTOX (onabotulinumtoxinA) for injection contains either 100 Units of Clostridium botulinum type A neurotoxin complex, 0.5 mg of Albumin Human, and 0.9 mg of sodium chloride; or 200 Units of Clostridium botulinum type A neurotoxin complex, 1 mg of Albumin Human, and 1.8 mg of sodium chloride in a sterile, vacuum-dried form without a preservative.” [Botox Prescription Guide]

Botox should not be used in people with known or unknown autoimmune disorders.

Very little is known about the long-term effects of using Botox with an autoimmune disorder. Botox is contraindicated for use for people who have the autoimmune disease Myasthenia Gravis. Its use is also warned against for those with neuromuscular diseases. Because of these warnings *Anyone with a known autoimmune disease or family history of them should proceed with uptmost caution. Anytime a foreign substance is injected into the body, it elicits an immune response. It is your body’s job, and its way of protecting you from a foreign invader. Botulinum toxin, the “world’s most lethal neurotoxin,” is a highly foreign invader.

Botulinum Neurotoxin Type A Induces TLR2-Mediated Inflammatory Responses in Macrophages

Yun Jeong Kim,Jeong-Hee Kim,Kwang-Jun Lee,Myung-Min Choi,Yeon Hee Kim,Gi-eun Rhie,Cheon-Kwon Yoo,Kiweon Cha